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Review Article| Volume 67, ISSUE 2, P259-280, April 2023

Pathogenesis and Differential Diagnosis of Temporomandibular Joint Disorders

Published:February 01, 2023DOI:https://doi.org/10.1016/j.cden.2022.10.001

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      References

        • Slade G.D.
        • Ohrbach R.
        • Greenspan J.D.
        • et al.
        Painful temporomandibular disorder: decade of discovery from OPERA studies.
        J Dent Res. 2016; 95: 1084-1092
        • Slade G.D.
        • Bair E.
        • Greenspan J.D.
        • et al.
        Signs and symptoms of first-onset TMD and sociodemographic predictors of its development: the OPPERA prospective cohort study.
        J Pain. 2013; 14: T20-T32 e1-3
        • Schiffman E.
        • Ohrbach R.
        • Trueloveet E.
        • et al.
        Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network∗ and Orofacial Pain Special Interest Groupdagger.
        J Oral Facial Pain Headache. 2014; 28: 6-27
        • Rongo R.
        • Ekberg E.
        • Nilsson I.
        • et al.
        Diagnostic criteria for temporomandibular disorders (DC/TMD) for children and adolescents: An international Delphi study-Part 1-Development of Axis I.
        J Oral Rehabil. 2021; 48: 836-845
        • Slade G.D.
        • Fillingim R.
        • Sanders A.
        • et al.
        Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions.
        J Pain. 2013; 14: T116-T124
        • Manfredini D.
        • Lombardo L.
        • Siciliani G.
        Temporomandibular disorders and dental occlusion. A systematic review of association studies: end of an era?.
        J Oral Rehabil. 2017; 44: 908-923
        • Gesch D.
        • Bernhardt O.
        • Kirbschus A.
        Association of malocclusion and functional occlusion with temporomandibular disorders (TMD) in adults: a systematic review of population-based studies.
        Quintessence Int. 2004; 35: 211-221
        • Kalladka M.
        • Young A.
        • Thomas D.
        • et al.
        The relation of temporomandibular disorders and dental occlusion: a narrative review.
        Quintessence Int. 2022; 53: 450-459
        • Bair E.
        • Ohrbach R.
        • Fillingim R.
        • et al.
        Multivariable modeling of phenotypic risk factors for first-onset TMD: the OPPERA prospective cohort study.
        J Pain. 2013; 14: T102-T115
        • Moin Anwer H.M.
        • Albagieh H.
        • Kalladka M.
        • et al.
        The role of the dentist in the diagnosis and management of pediatric obstructive sleep apnea.
        Saudi Dent J. 2021; 33: 424-433
        • Ozasa K.
        • Nishihara C.
        • Watanabe K.
        • et al.
        Somatosensory profile of a patient with mixed connective tissue disease and Sjogren syndrome.
        J Am Dent Assoc. 2020; 151: 145-151
        • Sanders A.E.
        • Slade G.
        • Bair E.
        • et al.
        General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study.
        J Pain. 2013; 14: T51-T62
        • Gaynor S.M.
        • Fillingim R.
        • Zolnounet D.
        • et al.
        Association of Hormonal Contraceptive Use with Headache and Temporomandibular Pain: The OPPERA Study.
        J Oral Facial Pain Headache. 2021; 35: 105-112
        • Markiewicz M.R.
        • Ohrbach R.
        • McCall Jr., W.D.
        Oral behaviors checklist: reliability of performance in targeted waking-state behaviors.
        J Orofac Pain. 2006; 20: 306-316
        • Ohrbach R.
        • Bair E.
        • Fillingim R.
        • Gonzalez Y.
        • et al.
        Clinical orofacial characteristics associated with risk of first-onset TMD: the OPPERA prospective cohort study.
        J Pain. 2013; 14: T33-T50
        • Sharma S.
        • Wactawski-Wende J.
        • LaMonte M.
        • et al.
        Incident injury is strongly associated with subsequent incident temporomandibular disorder: results from the OPPERA study.
        Pain. 2019; 160: 1551-1561
        • Slade G.D.
        • Sanders A.
        • Ohrbach R.
        • et al.
        Pressure pain thresholds fluctuate with, but do not usefully predict, the clinical course of painful temporomandibular disorder.
        Pain. 2014; 155: 2134-2143
        • Sanders A.E.
        • Essick G.
        • Fillingim R.
        • et al.
        Sleep apnea symptoms and risk of temporomandibular disorder: OPPERA cohort.
        J Dent Res. 2013; 92: 70S
        • Sanders A.E.
        • Akinkugbe A.
        • Fillingimet R.
        • et al.
        Causal mediation in the development of painful temporomandibular disorder.
        J Pain. 2017; 18: 428-436
        • Fillingim R.B.
        • Ohrbach R.
        • Greenspan J.
        • et al.
        Psychological factors associated with development of TMD: the OPPERA prospective cohort study.
        J Pain. 2013; 14: T75-T90
        • Aggarwal V.R.
        • Macfarlane G.
        • Farragher T.
        • et al.
        Risk factors for onset of chronic oro-facial pain--results of the North Cheshire oro-facial pain prospective population study.
        Pain. 2010; 149: 354-359
        • Dunn K.M.
        • Jordan K.
        • Mancl L.
        • et al.
        Trajectories of pain in adolescents: a prospective cohort study.
        Pain. 2011; 152: 66-73
        • LeResche L.
        • Mancl L.
        • Drangsholt M.
        • et al.
        Predictors of onset of facial pain and temporomandibular disorders in early adolescence.
        Pain. 2007; 129: 269-278
        • Fillingim R.B.
        • Ohrbach R.
        • Greenspan J.
        • et al.
        Associations of psychologic factors with multiple chronic overlapping pain conditions.
        J Oral Facial Pain Headache. 2020; 34: s85-s100
        • Euteneuer F.
        • Schwarz M.
        • Hennings A.
        • et al.
        Psychobiological aspects of somatization syndromes: contributions of inflammatory cytokines and neopterin.
        Psychiatry Res. 2012; 195: 60-65
        • Maes M.
        Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms.
        Curr Opin Psychiatry. 2009; 22: 75-83
        • Fillingim R.B.
        • Slade G.
        • Greenspan J.
        • et al.
        Long-term changes in biopsychosocial characteristics related to temporomandibular disorder: findings from the OPPERA study.
        Pain. 2018; 159: 2403-2413
        • Smith S.B.
        • Mir E.
        • Blair E.
        • et al.
        Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study.
        J Pain. 2013; 14: T91-T101 e1-3
        • Tchivileva I.E.
        • Ohrbach R.
        • Fillingim R.
        • et al.
        Temporal change in headache and its contribution to the risk of developing firstonset temporomandibular disorder in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study.
        Pain. 2017; 158: 120-129
        • Slade G.D.
        • Rosen J.
        • Ohrbach R.
        • et al.
        Anatomical selectivity in overlap of chronic facial and bodily pain.
        Pain Rep. 2019; 4: e729
        • Jensen R.
        Mechanisms of spontaneous tension-type headaches: an analysis of tenderness, pain thresholds and EMG.
        Pain. 1996; 64: 251-256
        • Morch C.D.
        • Hu J.
        • Arendt-Nielsen L.
        • et al.
        Convergence of cutaneous, musculoskeletal, dural and visceral afferents onto nociceptive neurons in the first cervical dorsal horn.
        Eur J Neurosci. 2007; 26: 142-154
        • Rodriguez E.
        • Sakurai K.
        • Xu J.
        • et al.
        A craniofacial-specific monosynaptic circuit enables heightened affective pain.
        Nat Neurosci. 2017; 20: 1734-1743
        • Scholz J.
        • Woolf C.J.
        The neuropathic pain triad: neurons, immune cells and glia.
        Nat Neurosci. 2007; 10: 1361-1368
        • Kaneyama K.
        • Segami N.
        • Sun W.
        • et al.
        Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 276-284
        • Lee J.K.
        • Cho Y.S.
        • Song S.I.
        Relationship of synovial tumor necrosis factor alpha and interleukin 6 to temporomandibular disorder.
        J Oral Maxillofac Surg. 2010; 68: 1064-1068
        • Harmon J.B.
        • Sanders A.
        • Wilder R.
        • et al.
        Circulating omentin-1 and chronic painful temporomandibular disorders.
        J Oral Facial Pain Headache. 2016; 30: 203-209
        • Slade G.D.
        • Conrad M.
        • Diatchenko L.
        • et al.
        Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.
        Pain. 2011; 152: 2802-2812
        • Cheng J.K.
        • Ji R.R.
        Intracellular signaling in primary sensory neurons and persistent pain.
        Neurochem Res. 2008; 33: 1970-1978
        • Zhang J.M.
        • An J.
        , Cytokines, inflammation, and pain.
        Int Anesthesiol Clin. 2007; 45: 27-37
        • Kaneyama K.
        • Segami N.
        • Nishimura M.
        • et al.
        Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders.
        Br J Oral Maxillofac Surg. 2002; 40: 418-423
        • Takahashi T.
        • Kondoh T.
        • Fukuda M.
        • et al.
        Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85: 135-141
        • Eliav E.
        • Benoliel R.
        • Herzberg H.
        • et al.
        The role of IL-6 and IL-1beta in painful perineural inflammatory neuritis.
        Brain Behav Immun. 2009; 23: 474-484
        • Kopp S.
        Neuroendocrine, immune, and local responses related to temporomandibular disorders.
        J Orofac Pain. 2001; 15: 9-28
        • Maixner W.
        • Diatchenko L.
        • Dubner R.
        • et al.
        Orofacial pain prospective evaluation and risk assessment study--the OPPERA study.
        J Pain. 2011; 12: T4-T11 e1-2
        • Khan J.
        • Wang Q.
        • Ren Y.
        • et al.
        Exercise induced hypoalgesia profile in rats is associated with IL-10 and IL-1 beta levels and pain severity following nerve injury.
        Cytokine. 2021; 143: 155540
        • Korczeniewska O.A.
        • Kuo F.
        • Huang C.
        • et al.
        Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.
        J Gene Med. 2021; 23: e3374
        • Bair E.
        • Gaynor S.
        • Slade G.
        • et al.
        Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study.
        Pain. 2016; 157: 1266-1278
        • Young A.
        • Gallia S.
        • Ryan J.
        • et al.
        Diagnostic tool using the diagnostic criteria for temporomandibular disorders: a randomized crossover-controlled, double-blinded, two-center study.
        J Oral Facial Pain Headache. 2021; 35: 241-252
        • Ahmad M.
        • Schiffman E.L.
        Temporomandibular joint disorders and orofacial pain.
        Dent Clin North Am. 2016; 60: 105-124
        • Manfredini D.
        Etiopathogenesis of disk displacement of the temporomandibular joint: a review of the mechanisms.
        Indian J Dent Res. 2009; 20: 212-221
        • Wang Z.H.
        • Zhao Y.P.
        • Ma X.C.
        Ankylosis of temporomandibular joint caused by psoriatic arthritis: a report of four cases with literature review.
        Chin J Dent Res. 2014; 17: 49-55
        • Kobayashi R.
        • Utsunomiya T.
        • Yamamoto H.
        • et al.
        Ankylosis of the temporomandibular joint caused by rheumatoid arthritis: a pathological study and review.
        J Oral Sci. 2001; 43: 97-101
        • Herford A.S.
        • Boyne P.J.
        Ankylosis of the jaw in a patient with fibrodysplasia ossificans progressiva.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 96: 680-684
        • Rongo R.
        • Alstergren P.
        • Ammendola L.
        • et al.
        Temporomandibular joint damage in juvenile idiopathic arthritis: diagnostic validity of diagnostic criteria for temporomandibular disorders.
        J Oral Rehabil. 2019; 46: 450-459
        • Long X.
        The relationship between temporomandibular joint ankylosis and condylar fractures.
        Chin J Dent Res. 2012; 15: 17-20
        • Abrahamsson H.
        • Eriksson L.
        • Abrahamsson P.
        • et al.
        Treatment of temporomandibular joint luxation: a systematic literature review.
        Clin Oral Investig. 2020; 24: 61-70
        • Muto T.
        • Kawakami J.
        • Kanazawa M.
        • et al.
        Development and histologic characteristics of synovitis induced by trauma in the rat temporomandibular joint.
        Int J Oral Maxillofac Surg. 1998; 27: 470-475
        • Dijkstra P.U.
        • Kropmans T.J.
        • Stegenga B.
        The association between generalized joint hypermobility and temporomandibular joint disorders: a systematic review.
        J Dent Res. 2002; 81: 158-163
        • Kalladka M.
        • Quek S.
        • Heir G.
        • et al.
        Temporomandibular joint osteoarthritis: diagnosis and long-term conservative management: a topic review.
        J Indian Prosthodont Soc. 2014; 14: 6-15
        • Peck C.C.
        • Goulet J.-P.
        • Lobbezoo F.
        • et al.
        Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders.
        J Oral Rehabil. 2014; 41: 2-23
      1. International Classification of Orofacial Pain, 1st edition (ICOP).
        Cephalalgia Int J Headache. 2020; 40: 129-221
        • Nicolielo L.F.P.
        • Jacobs R.
        • Albdour E.
        • et al.
        Is oestrogen associated with mandibular condylar resorption? A systematic review.
        Int J Oral Maxillofac Surg. 2017; 46: 1394-1402
        • Ivask O.
        • Leibur E.
        • Voog-Oras U.
        Synovial chondromatosis in the temporomandibular joint: case report with review of the literature.
        Stomatologija. 2015; 17: 97-101
        • Robinson D.
        • Hasharoni A.
        • Cohen N.
        • et al.
        Fibroblast growth factor receptor-3 as a marker for precartilaginous stem cells.
        Clin Orthop Relat Res. 1999; 367: S163-S175
        • Fujita S.
        • Iizuka T.
        • Yoshida H.
        • et al.
        Transforming growth factor and tenascin in synovial chondromatosis of the temporomandibular joint. Report of a case.
        Int J Oral Maxillofac Surg. 1997; 26: 258-259
        • Li Y.
        • Zhou Y.
        • Wang Y.
        • et al.
        Synovial macrophages in cartilage destruction and regeneration-lessons learnt from osteoarthritis and synovial chondromatosis.
        Biomed Mater. 2021; 17
        • Ferguson M.
        Rhinosinusitis in oral medicine and dentistry.
        Aust Dent J. 2014; 59: 289-295
        • Williams J.W.
        • Simel D.L.
        Does this patient have sinusitis? Diagnosing acute sinusitis by history and physical examination.
        JAMA. 1993; 270: 1242-1246
        • Shivhare P.
        • Shankarnarayan L.
        • Usha
        • et al.
        Condylar aplasia and hypoplasia: a rare case.
        Case Rep Dent. 2013; 2013: 745602
        • Kalladka M.
        • Young A.
        • Khan J.
        Myofascial pain in temporomandibular disorders: Updates on etiopathogenesis and management.
        J Bodyw Mov Ther. 2021; 28: 104-113
        • Wolfe F.
        • Clauw D.J.
        • Fitzcharles M.A.
        • et al.
        The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity.
        Arthritis Care Res. 2010; 62: 600-610
        • Sluka K.A.
        • Clauw D.J.
        Neurobiology of fibromyalgia and chronic widespread pain.
        Neuroscience. 2016; 338: 114-129
        • Dando W.E.
        • Branch M.A.
        • Maye J.P.
        Headache disability in orofacial pain patients.
        Headache. 2006; 46: 322-326
        • Olesen J.
        International classification of headache disorders.
        Lancet Neurol. 2018; 17: 396-397
        • Teruel A.
        • Romero-Reyes M.
        Interplay of oral, mandibular, and facial disorders and migraine.
        Curr Pain Headache Rep. 2022; 26: 517-523
        • Covert L.
        • Mater H.V.
        • Hechler B.L.
        Comprehensive management of rheumatic diseases affecting the temporomandibular joint.
        Diagnostics (Basel). 2021; 11